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Article

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

28 Nov 2018

Abstract excerpt

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have employed primary or immortalised podocyte cell lines cultured in 2D. Here we compare 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney...

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PMID: 30514835
DOI: 10.1038/s41467-018-07594-z

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