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Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis

2021-05-27

Abstract excerpt

Human organoids allow studying proliferation, lineage specification, and three-dimensional tissue development. Due to the inherent multicellular complexity, interrogation by systematic genetic methodologies is challenging. Here, we present the first genome-wide CRISPR screen in iPSC-derived kidney organoids. The combination of genome editing, longitudinal sampling and sorting of specific cell populations enabled u...

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Literature Corpus work
e2161cfc-0af4-58c7-8eb7-d233b310e404
DOI
10.1101/2021.05.26.445745
Open publication

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Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesisDOI 10.1101/2021.05.26.445745
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