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Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development

14 Sept 2017

Abstract excerpt

Abstract A critical event during kidney organogenesis is the differentiation of podocytes, specialized epithelial cells that filter blood plasma to form urine. Podocytes derived from human pluripotent stem cells (hPSC-podocytes) have recently been generated in nephron-like kidney organoids, but the developmental stage of these cells and their capacity to reveal disease mechanisms remains unclear. Here, we show...

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PMID: 28905451
DOI: 10.1002/stem.2707

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