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A chimeric human-mouse lung vascular model using induced pluripotent stem cells reveals insights into the pathogenesis of <i>BMPR2</i> -related pulmonary hypertension

2026-05-02

Abstract excerpt

Advances in tissue biology have revealed remarkable transcriptomic heterogeneity of endothelial cells between and within organ systems. This necessitates more precise models of organ-specific endothelium to understand the pathogenesis of genetic vascular disorders, such as pulmonary hypertension (PH), where gene-disease associations have implicated endothelial cell dysfunction as a key driver of disease pathogenes...

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Literature Corpus work
dd09f7ab-7300-5454-8873-79b9d150fbde
DOI
10.64898/2026.04.29.721664
Open publication

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A chimeric human-mouse lung vascular model using induced pluripotent stem cells reveals insights into the pathogenesis of <i>BMPR2</i> -related pulmonary hypertensionDOI 10.64898/2026.04.29.721664
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