Article

Comparative single-cell atlases reveal injury-driven tubal epithelial regeneration as a window for ovarian carcinoma initiation

2026-03-30

Abstract excerpt

High-grade serous carcinoma (HGSC), the most lethal form of ovarian cancer, preferentially originates in the tubal epithelium (TE) of the distal uterine tube (also known as Fallopian tube or oviduct). Mouse models are widely used to study how HGSC initiates in humans; however, the extent to which mouse and human uterine tubes are comparable remains unclear. Here, we conduct cross-species single-cell transcriptomic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d1935f0-f4ac-5fde-a08b-600a25fc6cc5
DOI: 10.64898/2026.03.26.714557

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative single-cell atlases reveal injury-driven tubal epithelial regeneration as a window for ovarian carcinoma initiationDOI 10.64898/2026.03.26.714557Read

In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cellsSemantic proximity Read

Single-cell analysis defines the lineage plasticity of stem cells in cervix epitheliumSemantic proximity Read

Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived OrganoidsSemantic proximity Read

Aged and BRCA -Mutated Stromal Cells Drive Epithelial Cell TransformationSemantic proximity Read

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.Semantic proximity Read

Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tubeSemantic proximity Read

Rete Ovarii Epithelial Cells as an Unappreciated Cell of Origin for Pelvic and Ovarian High-Grade Serous CarcinomaSemantic proximity Read

A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencingSemantic proximity Read

Lineage-Specific Epigenomic Mapping of Proximal and Distal Fallopian Tube Epithelium Reveals Mesenchymal/Wnt-Driven Tumor Phenotype DiversificationSemantic proximity Read

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populationsSemantic proximity Read

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma.Semantic proximity Read

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populationsSemantic proximity Read