Article

Lineage-Specific Epigenomic Mapping of Proximal and Distal Fallopian Tube Epithelium Reveals Mesenchymal/Wnt-Driven Tumor Phenotype Diversification

2025-09-01

Abstract excerpt

<h4>ABSTRACT</h4> High-grade serous ovarian cancer (HGSC) typically originates from the distal fallopian tube epithelium (disFTE), while the proximal epithelium (proFTE) remains less explored. Here, Using isogenic murine organoid models with common oncogenic drivers ( Tp53 −/− ; Kras mut ; Pten −/− ), we show that disFTE and proFTE generate distinct tumor subtypes driven by region-specific transcriptional pro...

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Literature Corpus work: e7658aaa-0c6a-5389-a85e-ef1224cb9b4b
DOI: 10.1101/2025.08.27.672603

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