Article
Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube
1 Apr 2021
Abstract excerpt
The human fallopian tube harbors the cell of origin for the majority of high-grade serous "ovarian" cancers (HGSCs), but its cellular composition, particularly the epithelial component, is poorly characterized. We perform single-cell transcriptomic profiling of around 53,000 individual cells from 12 primary fallopian specimens to map their major cell types. We identify 10 epithelial subpopulations with diverse...
Topics
Join the communities discussing this publication.