Article

Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 Channels

2025-01-11

Abstract excerpt

<h4>Summary</h4> Engineering infrared light sensitivity in the blind human retina could restore visual function in patients with regional retinal degeneration. However, current approaches are complex and contain non-human biological components. Using rational protein design we engineered human TRPV1 channels (Δ786-840) with temperature sensitivity shifted from 45 to 41°C that enabled near-infrared light- induced...

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Literature Corpus work: 3d0e2448-9aef-57a1-b6e7-6f5ad8cc6aa2
DOI: 10.1101/2025.01.08.631889

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