Article

Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics

2024-10-18

Abstract excerpt

<h4> Abstract </h4> Sonogenetics offers non-invasive and cell-type specific modulation of cells genetically engineered to express ultrasound-sensitive actuators. Finding an ion channel to serve as sonogenetic actuator it critical for advancing this promising technique. Here, we show that ultrasound can activate human TRP channel hTRPV4. By screening different hTRPV4 variants, we identify a mutation F617L that in...

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Literature Corpus work: 18795093-dd34-5bc8-a17c-732b8661f15f
DOI: 10.1101/2024.10.16.618766

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