Article

Efficient and sustained optogenetic control of sensory and cardiac systems

2023-11-18

Abstract excerpt

Optogenetic control is used to manipulate the activity of specific cell types in vivo for a variety of biological and clinical applications. Here we report ChReef, an improved variant of the channelrhodopsin ChRmine. ChReef offers minimal photocurrent desensitization, a unitary conductance of 80 fS and closing kinetics of 30 ms, which together enable reliable optogenetic control of cells at low light levels with...

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Literature Corpus work: d258568c-f266-5e3c-9b03-b3390764f406
DOI: 10.1101/2023.11.17.567544

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