Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation.

Nature neuroscience - 1 Oct 2013

Lin John Y, Knutsen Per Magne, Muller Arnaud, Kleinfeld David, Tsien Roger Y

Abstract excerpt

Channelrhodopsins (ChRs) are used to optogenetically depolarize neurons. We engineered a variant of ChR, denoted red-activatable ChR (ReaChR), that is optimally excited with orange to red light (λ ∼590-630 nm) and offers improved membrane trafficking, higher photocurrents and faster kinetics compared to existing red-shifted ChRs. Red light is less scattered by tissue and is absorbed less by blood than the blue to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Brain
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Optogenetics

Share to Photic Stimulation

Share to Rats, Sprague-Dawley

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 23995068
DOI: 10.1038/nn.3502
PMCID: PMC3793847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation.PMID 23995068Read ↗

High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics.Semantic proximity Read ↗

Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.Semantic proximity Read ↗

Efficient and sustained optogenetic control of sensory and cardiac systemsSemantic proximity Read ↗

A user's guide to channelrhodopsin variants: features, limitations and future developments.Semantic proximity Read ↗

Photochemical activation of TRPA1 channels in neurons and animals.Semantic proximity Read ↗

The high-light-sensitivity mechanism and optogenetic properties of the bacteriorhodopsin-like channelrhodopsin GtCCR4.Semantic proximity Read ↗

Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways.Semantic proximity Read ↗

Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 ChannelsSemantic proximity Read ↗

Optogenetic Control of Mammalian Ion Channels with Chemical Photoswitches.Semantic proximity Read ↗

Long-term all-optical interrogation of cortical neurons in awake-behaving non-human primatesSemantic proximity Read ↗

Conductance mechanisms of rapidly desensitizing cation channelrhodopsins from cryptophyte algaeSemantic proximity Read ↗

Remote control of neuronal activity with a light-gated glutamate receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.