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Article

Photochemical activation of TRPA1 channels in neurons and animals.

Nature chemical biology - 1 Apr 2013

Kokel David, Cheung Chung Yan J, Mills Robert, Coutinho-Budd Jaeda, Huang Liyi, Setola Vincent, Sprague Jared, Jin Shan, Jin Youngnam N, Huang Xi-Ping, Bruni Giancarlo, Woolf Clifford J, Roth Bryan L, Hamblin Michael R, Zylka Mark J, Milan David J, Peterson Randall T

Abstract excerpt

Optogenetics is a powerful research tool because it enables high-resolution optical control of neuronal activity. However, current optogenetic approaches are limited to transgenic systems expressing microbial opsins and other exogenous photoreceptors. Here, we identify optovin, a small molecule that enables repeated photoactivation of motor behaviors in wild-type zebrafish and mice. To our surprise, optovin's...

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Identifiers

PMID: 23396078
DOI: 10.1038/nchembio.1183
PMCID: PMC3604056

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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