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Automated GMP-Compatible Production of Universal CAR Tregs for Organ-Targeted Tolerance Induction

2025-08-25

Abstract excerpt

<title>Abstract</title> <p> Background Adoptive transfer of regulatory T cells (Tregs) has demonstrated safety, feasibility and early signs of efficacy in promoting immunological tolerance in inflammatory conditions such as graft-versus-host disease (GvHD). Chimeric antigen receptor (CAR)-engineered Tregs offer localized activation and suppression compared to polyclonal Tregs, but their clinical translation is l...

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Literature Corpus work
c1bb6236-c2a0-5993-81bd-ae1aef50a9d6
DOI
10.21203/rs.3.rs-7416434/v1
Open publication

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