Article

A stage-specific protein factor binding to a CACCC motif in both human beta-globin gene promoter and 5^-HS2 region

1994-01-01

Abstract excerpt

The DNaseI hypersensitive site 2 (HS2) of human beta-globin locus control region (LCR) is required for the high level expression of human beta-globin genes. In the present study, a stage-specific protein factor (LPF-beta) was identified in the nuclear extract prepared from mouse fetal liver at d 18 of gestation, which could bind to the HS2 region of human beta-globin LCR. We also found that the shift band of LPF-b...

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Literature Corpus work: 3ce9d5be-84e9-528a-b075-6be4f4ef561b
DOI: 10.1038/cr.1994.14

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