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Article

Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity.

Nucleic acids research - 15 Jul 2000

Ryan T M, Sun C W, Ren J, Townes T M

Abstract excerpt

The persistence of fetal hemoglobin in many patients with deletion type beta thalassemias and the expression patterns of human globin genes in transgenic mice suggest that gamma- to beta-globin gene switching results primarily from competition of gamma- and beta-globin genes for interaction with the beta-globin locus control region (LCR). To define regulatory sequences that are essential for the competitive...

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Identifiers

PMID: 10908330
DOI: 10.1093/nar/28.14.2736
PMCID: PMC102642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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