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Article

Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner.

Nucleic acids research - 1 Jan 2006

Li Qiliang, Fang Xiangdong, Olave Ivan, Han Hemei, Yu Man, Xiang Ping, Stamatoyannopoulos George

Abstract excerpt

To test the role of CACCC box on gamma-globin gene activation, the CACCC box was deleted or mutated and gamma-gene expression was monitored in transgenic mice. Disruption of the CACCC box had no effect on gamma-gene expression in the cells of embryonic erythropoiesis but it strikingly reduced gamma-gene expression in fetal erythropoiesis, and abolished gamma-gene expression in adult erythroid cells. The CACCC...

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Source

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Identifiers

PMID: 16914453
DOI: 10.1093/nar/gkl474
PMCID: PMC1557803

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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