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Article

The higher structure of chromatin in the LCR of the beta-globin locus changes during development.

Journal of molecular biology - 27 Nov 2009

Fang Xiangdong, Yin Wenxuan, Xiang Ping, Han Hemei, Stamatoyannopoulos George, Li Qiliang

Abstract excerpt

The beta-globin locus control region (LCR) is able to enhance the expression of all globin genes throughout the course of development. However, the chromatin structure of the LCR at the different developmental stages is not well defined. We report DNase I and micrococcal nuclease hypersensitivity, chromatin immunoprecipitation analyses for histones H2A, H2B, H3, and H4, and 3C (chromatin conformation capture)...

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Identifiers

PMID: 19781549
DOI: 10.1016/j.jmb.2009.09.046
PMCID: PMC2849742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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