The mouse beta-globin locus control region: hypersensitive sites 3 and 4.

doi:10.1093/nar/20.21.5797

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Article

The mouse beta-globin locus control region: hypersensitive sites 3 and 4.

Nucleic acids research - 11 Nov 1992

Jiménez G, Gale K B, Enver T

Abstract excerpt

The human beta-globin LCR plays a key role in the transcriptional regulation of the beta-globin locus and comprises four erythroid specific DNase I hypersensitive sites, designated 5'HS1-4. We have now isolated genomic clones containing 5'HS3 and 5'HS4 of the mouse beta-globin LCR. 5'HS3 and 5'HS4 are located 15 kb and 22 kb upstream of the mouse epsilon y-globin gene, respectively. Sequence analysis of murine...

Topics

Animals
Base Sequence
Biological Evolution
Cell Line
Cloning, Molecular
DNA
Deoxyribonuclease I
Genetic Variation
Globins
Hematopoietic Stem Cells
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Inbred DBA

Molecular Sequence Data

Regulatory Sequences, Nucleic Acid

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 1454540
DOI: 10.1093/nar/20.21.5797
PMCID: PMC334418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1454540-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The mouse beta-globin locus control region: hypersensitive sites 3 and 4.PMID 1454540Read ↗

Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human beta-globin locus control region.Semantic proximity Read ↗

Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.Semantic proximity Read ↗

Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Semantic proximity Read ↗

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.Semantic proximity Read ↗

The higher structure of chromatin in the LCR of the beta-globin locus changes during development.Semantic proximity Read ↗

Reconstitution of Human β-Globin Locus Control Region Hypersensitive Sites in the Absence of Chromatin AssemblySemantic proximity Read ↗

The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.Semantic proximity Read ↗

Human β-Globin Locus Control Region HS5Contains CTCF- and Developmental Stage-Dependent Enhancer-BlockingActivity in ErythroidCellsSemantic proximity Read ↗

Identification of a homolog of the C alpha 3'/hs3 enhancer and of an allelic variant of the 3'IgH/hs1,2 enhancer downstream of the human immunoglobulin alpha 1 gene.Semantic proximity Read ↗

Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.Semantic proximity Read ↗

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.Semantic proximity Read ↗

Heterozygosity for deletion of hypersensitive site 3 in the human locus control region has an unexpected minor effect on red cell phenotype.Semantic proximity Read ↗

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