Article

Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safety

2025-12-16

Abstract excerpt

The nuclear receptor PPARγ is a primary therapeutic target for insulin resistance and type 2 diabetes (T2D); however, its thiazolidinedione (TZD) class of PPARγ agonists have substantial safety concerns in clinical utilization. Genetic inhibition of PPARγ acetylation at K268 and K293 dissociates the major adverse effects of TZDs from insulin sensitization and other metabolic improvements. We therefore posit that c...

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Literature Corpus work: 3ce92bd7-128e-5c46-bcc3-adeef36e9050
DOI: 10.64898/2025.12.15.694265

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