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Article

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.

Cell - 3 Aug 2012

Qiang Li, Wang Liheng, Kon Ning, Zhao Wenhui, Lee Sangkyu, Zhang Yiying, Rosenbaum Michael, Zhao Yingming, Gu Wei, Farmer Stephen R, Accili Domenico

Abstract excerpt

Brown adipose tissue (BAT) can disperse stored energy as heat. Promoting BAT-like features in white adipose (WAT) is an attractive, if elusive, therapeutic approach to staunch the current obesity epidemic. Here we report that gain of function of the NAD-dependent deacetylase SirT1 or loss of function of its endogenous inhibitor Deleted in breast cancer-1 (Dbc1) promote "browning" of WAT by deacetylating...

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Identifiers

PMID: 22863012
DOI: 10.1016/j.cell.2012.06.027
PMCID: PMC3413172

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