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Article

Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.

Oncotarget - 15 Sept 2014

Tian Lifeng, Wang Chenguang, Hagen Fred K, Gormley Michael, Addya Sankar, Soccio Raymond, Casimiro Mathew C, Zhou Jie, Powell Michael J, Xu Ping, Deng Haiteng, Sauve Anthony A, Pestell Richard G

Abstract excerpt

In our prior publications we characterized a conserved acetylation motif (K(R)xxKK) of evolutionarily related nuclear receptors. Recent reports showed that peroxisome proliferator activated receptor gamma (PPARγ) deacetylation by SIRT1 is involved in delaying cellular senescence and maintaining the brown remodeling of white adipose tissue. However, it still remains unknown whether lysyl residues 154 and 155...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25229978
DOI: 10.18632/oncotarget.2371
PMCID: PMC4202124

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.PMID 25229978Read ↗

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Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safetySemantic proximity Read ↗

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.Semantic proximity Read ↗

SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cellsSemantic proximity Read ↗

Acetylation of FOXM1 is essential for its transactivation and tumor growth stimulationSemantic proximity Read ↗

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Ligand binding reduces SUMOylation of the peroxisome proliferator-activated receptor γ (PPARγ) activation function 1 (AF1) domain.Semantic proximity Read ↗

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