Article

TPR is required for the nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes

2019-08-20

Abstract excerpt

While splicing has been shown to enhance nuclear export, it has remained unclear whether mRNAs generated from intronless genes use specific machinery to promote their export. Here we investigate the role of the major nuclear pore basket protein, TPR, in regulating mRNA and lncRNA nuclear export in human cells. By sequencing mRNA from the nucleus and cytosol of control and TPR-depleted cells, we provide evidence th...

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Literature Corpus work: 226315d6-1570-57c3-acd3-4eb1cff35cfe
DOI: 10.1101/740498

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