Article

Modification-aware AI enables terminal chemical modifications for peptide design and discovers potent antimicrobials

2026-04-10

Abstract excerpt

<h4>Summary</h4> Antimicrobial resistance (AMR) is an escalating global health threat, intensifying the urgent need for novel antibiotics. Here, we introduce Termini, a generative machine learning (ML) framework that integrates peptide generation, classification, and regression modules to systematically identify potent antimicrobial peptides (AMPs). A key feature of this pipeline is its explicit design of both N-...

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Literature Corpus work: 51796891-7ac3-5de7-95b3-835faa1016ed
DOI: 10.64898/2026.04.09.717597

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