Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of DNA Methylation Is Linked to Genetic Aberrations in Chronic Lymphocytic Leukemia

19 Dec 2013

Abstract excerpt

Abstract Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays and next-generation sequencing to evaluate intratumor heterogeneity and evolution of DNA methylation and genetic aberrations in chronic lymphocytic leukemia (CLL). CLL cases exhibit vast interpatient differences in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Chronic Lymphocytic Leukemia Research
Share to Genomic variations and chromosomal abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24356097
DOI: 10.1158/2159-8290.cd-13-0349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of DNA Methylation Is Linked to Genetic Aberrations in Chronic Lymphocytic LeukemiaPMID 24356097Read ↗

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.Semantic proximity Read ↗

Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemiaSemantic proximity Read ↗

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

Clonal Evolution of High-Risk Chronic Lymphocytic Leukemia: A Contemporary PerspectiveSemantic proximity Read ↗

Molecular pathogenesis of CLL and its evolution.Semantic proximity Read ↗

Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development.Semantic proximity Read ↗

Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia.Semantic proximity Read ↗

Genetic and epigenetic determinants of B-cell lymphoma evolution.Semantic proximity Read ↗

Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcomeSemantic proximity Read ↗

Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns.Semantic proximity Read ↗

Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia.Semantic proximity Read ↗

Deciphering the molecular landscape in chronic lymphocytic leukemia: time frame of disease evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.