Article
Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice.
Journal of lipid research - 1 Jul 2009
Atshaves Barbara P, McIntosh Avery L, Martin Gregory G, Landrock Danilo, Payne H Ross, Bhuvanendran Shivaprasad, Landrock Kerstin K, Lyuksyutova Olga I, Johnson Jeffery D, Macfarlane Ronald D, Kier Ann B, Schroeder Friedhelm
Abstract excerpt
Although in vitro studies suggest a role for sterol carrier protein-2 (SCP-2) in cholesterol trafficking and metabolism, the physiological significance of these observations remains unclear. This issue was addressed by examining the response of mice overexpressing physiologically relevant levels of SCP-2 to a cholesterol-rich diet. While neither SCP-2 overexpression nor cholesterol-rich diet altered food...
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