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Article

Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis.

Gastroenterology - 1 Oct 2011

Van Rooyen Derrick M, Larter Claire Z, Haigh W Geoffrey, Yeh Matthew M, Ioannou George, Kuver Rahul, Lee Sum P, Teoh Narci C, Farrell Geoffrey C

Abstract excerpt

BACKGROUND & AIMS: Type 2 diabetes and nonalcoholic steatohepatitis (NASH) are associated with insulin resistance and disordered cholesterol homeostasis. We investigated the basis for hepatic cholesterol accumulation with insulin resistance and its relevance to the pathogenesis of NASH. METHODS: Alms1 mutant (foz/foz) and wild-type NOD.B10 mice were fed high-fat diets that contained varying percentages of...

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Identifiers

PMID: 21703998
DOI: 10.1053/j.gastro.2011.06.040
PMCID: PMC3186822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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