Article

Mitochondrial dysfunction impairs human neuronal development and reduces neuronal network activity and synchronicity

2019-07-30

Abstract excerpt

<h4>Summary</h4> Epilepsy, intellectual and cortical sensory deficits and psychiatric manifestations are among the most frequent manifestations of mitochondrial diseases. Yet, how mitochondrial dysfunction affects neural structure and function remains largely elusive. This is mostly due to the lack of a proper in vitro translational neuronal model system(s) with impaired energy metabolism. Leveraging the induced...

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Literature Corpus work: 52367bbb-709d-51cf-b891-fe62cfe7868e
DOI: 10.1101/720227

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