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Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons

2020-08-12

Abstract excerpt

<h4>Summary</h4> Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is often caused by an adenine to guanine mutation at m.3243 (m.3243A>G) of the MT-TL1 gene (tRNA leu(UUR) ). To understand how this mutation affects the nervous system, we differentiated human induced-pluripotent stem cells (iPSCs) into excitatory neurons with normal (low heteroplasmy) and impaired (high heteropla...

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Literature Corpus work
d530b4bd-a69f-5e29-9de1-39e5ea386d0c
DOI
10.1101/2020.08.11.246140
Open publication

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Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neuronsDOI 10.1101/2020.08.11.246140
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