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Article

Validation of behavioral phenotypes in the BACHD rat model.

Behavioural brain research - 1 Sept 2020

Novati Arianna, Manfré Giuseppe, Flunkert Stefanie, Van der Harst Johanneke E, Homberg Judith R, Wronski Robert, Nguyen Huu Phuc

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion in the HTT gene. Various HD animal models have been generated to mimic the motor, cognitive and neuropsychiatric disturbances that affect HD patients. Reproducing disease phenotypes within these models is essential to identify reliable readouts for therapy studies. We validated behavioral phenotypes shown earlier by other...

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PMID: 32574646
DOI: 10.1016/j.bbr.2020.112783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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