Article
Early Detection of Apathetic Phenotypes in Huntington's Disease Knock-in Mice Using Open Source Tools.
Scientific reports - 2 Feb 2018
Minnig Shawn, Bragg Robert M, Tiwana Hardeep S, Solem Wes T, Hovander William S, Vik Eva-Mari S, Hamilton Madeline, Legg Samuel R W, Shuttleworth Dominic D, Coffey Sydney R, Cantle Jeffrey P, Carroll Jeffrey B
Abstract excerpt
Apathy is one of the most prevalent and progressive psychiatric symptoms in Huntington's disease (HD) patients. However, preclinical work in HD mouse models tends to focus on molecular and motor, rather than affective, phenotypes. Measuring behavior in mice often produces noisy data and requires large cohorts to detect phenotypic rescue with appropriate power. The operant equipment necessary for measuring...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.