Article

Early Detection of Apathetic Phenotypes in Huntington’s Disease Knock-in Mice Using Open Source Tools

2017-10-25

Abstract excerpt

Apathy is one of the most prevalent and progressive psychiatric symptom in Huntington’s disease (HD) patients. However, preclinical work in HD mouse models tend to focus on molecular and motor, rather than affective, phenotypes. Measuring behavior in mice often produces noisy data and requires large cohorts to detect phenotypic rescue with appropriate power. The operant equipment necessary for measuring affective...

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Literature Corpus work: 4f3ff67a-77fe-5b68-a43d-a4ea8471f4cb
DOI: 10.1101/208520

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