Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates.

PloS one - 1 Jan 2018

Manfré Giuseppe, Novati Arianna, Faccini Ilaria, Rossetti Andrea C, Bosch Kari, Molteni Raffaella, Riva Marco A, Van der Harst Johanneke E, Nguyen Huu Phuc, Homberg Judith R

Abstract excerpt

BACKGROUND: Huntington disease (HD) is a devastating inherited neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms without any cure to slow down or stop the progress of the disease. The BACHD rat model for HD carrying the human full-length mutant huntingtin protein (mHTT) with 97 polyQ repeats has been recently established as a promising model which reproduces...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corpus Striatum

Share to Huntingtin Protein

Share to Huntington Disease

Share to Receptors, Dopamine D1

Share to Receptors, Dopamine D2

Share to Social Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 29415038
DOI: 10.1371/journal.pone.0192289
PMCID: PMC5802907

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates.PMID 29415038Read ↗

Assessment of motor function, sensory motor gating and recognition memory in a novel BACHD transgenic rat model for huntington disease.Semantic proximity Read ↗

Cognitive impairments in a mouse model for Huntington’s disease correlate with presymptomatic locomotion and number of CAG repeatsSemantic proximity Read ↗

Validation of behavioral phenotypes in the BACHD rat model.Semantic proximity Read ↗

Sexual behavior and testis morphology in the BACHD rat model.Semantic proximity Read ↗

Sex-Dependent Changes in Social Behaviors in Motor Pre-Symptomatic R6/1 MiceSemantic proximity Read ↗

Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease.Semantic proximity Read ↗

A Novel BACHD Transgenic Rat Exhibits Characteristic Neuropathological Features of Huntington DiseaseSemantic proximity Read ↗

Detection of early behavioral markers of Huntington's disease in R6/2 mice employing an automated social home cage.Semantic proximity Read ↗

Constitutive depletion of brain serotonin differentially affects rats’ social and cognitive abilitiesSemantic proximity Read ↗

Novel ethological endophenotypes in a transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel.Semantic proximity Read ↗

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.