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Article

Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis.

Neurobiology of disease - 1 Jun 2017

Schwab L C, Richetin K, Barker R A, Déglon N

Abstract excerpt

Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by a triad of motor, psychiatric and cognitive deficits with the latter classically attributed to disruption of fronto-striatal circuits. However, emerging evidence suggests that some of the cognitive deficits in HD may have their origin in other structures including the hippocampus. Hippocampal abnormalities have been reported in HD...

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Identifiers

PMID: 28286179
DOI: 10.1016/j.nbd.2017.03.005

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