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Article

Cellular mechanisms of beta-amyloid production and secretion.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 1999

Sinha S, Lieberburg I

Abstract excerpt

The major constituent of senile plaques in Alzheimer's disease is a 42-aa peptide, referred to as beta-amyloid (Abeta). Abeta is generated from a family of differentially spliced, type-1 transmembrane domain (TM)-containing proteins, called APP, by endoproteolytic processing. The major, relatively ubiquitous pathway of APP metabolism in cell culture involves cleavage by alpha-secretase, which cleaves within the...

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Identifiers

PMID: 10500121
DOI: 10.1073/pnas.96.20.11049
PMCID: PMC34239

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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