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Article

Elevation of p11 in lateral habenula mediates depression-like behavior

16 May 2017

Abstract excerpt

The lateral habenula (LHb) is a key brain region involved in the pathophysiology of depression. It is activated by stimuli associated with negative experiences and is involved in encoding aversive signals. Hyperactivity of LHb is found in both rodent models of depression and human patients with depression. However, little is known about the underlying molecular mechanisms. Here we show that in LHb neurons, p11, a...

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PMID: 28507317
DOI: 10.1038/mp.2017.96

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