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Article

Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility.

Nature communications - 16 Feb 2023

Xu Fengzhe, Yu Evan Yi-Wen, Cai Xue, Yue Liang, Jing Li-Peng, Liang Xinxiu, Fu Yuanqing, Miao Zelei, Yang Min, Shuai Menglei, Gou Wanglong, Xiao Congmei, Xue Zhangzhi, Xie Yuting, Li Sainan, Lu Sha, Shi Meiqi, Wang Xuhong, Hu Wensheng, Langenberg Claudia, Yang Jian, Chen Yu-Ming, Guo Tiannan, Zheng Ju-Sheng

Abstract excerpt

Identification of protein quantitative trait loci (pQTL) helps understand the underlying mechanisms of diseases and discover promising targets for pharmacological intervention. For most important class of drug targets, genetic evidence needs to be generalizable to diverse populations. Given that the majority of the previous studies were conducted in European ancestry populations, little is known about the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36797296
DOI: 10.1038/s41467-023-36491-3
PMCID: PMC9935862

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