Article

Pro-inflammatory cytokines disrupt β-cell circadian clocks in diabetes

2019-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Intrinsic β-cell circadian clocks are a prerequisite for the control of glucose homeostasis through regulation of β-cell function and turnover. However, little is known about the contributions of circadian clock disruption to the natural progression of β-cell failure in diabetes. To address this, we examined the effects of cytokine-mediated inflammation, common to the pathophysiology of Type 1 a...

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Literature Corpus work: e938178a-1535-506f-9e06-89e94832ea3a
DOI: 10.1101/705210

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