Article

G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered TCR-T cells against hepatocellular carcinoma

2021-12-22

Abstract excerpt

<title>Abstract</title> <p>Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term adverse side-effects. However, multiple rounds of treatment are often required, increasing patient discomfort and cost. To mitigate this, we sought to improve the antitumor activity of transient engineered T...

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Literature Corpus work: 3c5c9dbc-d868-5651-ae07-015258ae3ee2
DOI: 10.21203/rs.3.rs-1154768/v1

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