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Article

Experimental Treatment of Colorectal Cancer in Mice with Human T Cells Electroporated with NKG2D RNA CAR

22 Jun 2020

Abstract excerpt

Aim: Peritoneal metastasis is often present in end-stage neoplastic diseases, including recurrent colorectal cancer and is associated with decreased overall survival. Novel methods are needed. Materials & methods: We constructed first-, second- and third-generation chimeric antigen receptors (CARs) specific for NKG2D ligands and modified human T cells with mRNA electroporation. Results: NKG2D CAR expression was...

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PMID: 32571133
DOI: 10.2217/imt-2019-0137

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