Article

KLRG1-deficient CAR-T cells exhibit superior antitumor efficacy against colorectal cancer cell lines by modulating the ZAP70/ERK signaling axis

2026-02-12

Abstract excerpt

<title>Abstract</title> The incidence of colorectal cancer (CRC) is on the rise globally, necessitating new treatment options. CRC cells highly express cadherins, which can suppress CAR-T cell function by engaging the inhibitory receptor KLRG1. The current study aimed to enhance CAR-T cell therapy by targeting the inhibitory axis mentioned. To achieve this, a KLRG1-downregulated CAR-T cell product (shK1-CAR-T)...

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Literature Corpus work: 8cc1e968-0ea5-5379-bfc7-14f9556d4b7a
DOI: 10.21203/rs.3.rs-8827661/v1

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