Article

CRISPR engineering of armored CAR T cells enables tumor restricted payload delivery with enhanced efficacy and safety

2025-04-28

Abstract excerpt

<title>Abstract</title> The efficacy of chimeric antig en receptor (CAR) T cell therapy in solid tumors is limited by immunosuppression and antigen heterogeneity. To overcome these barriers, “armored” CAR T cells, which secrete proinflammatory cytokines, have been developed. However, their clinical application has been limited due to toxicities related to peripheral expression of the armoring transgene. Here,...

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Literature Corpus work: e0864b16-89b6-5e6d-b390-2fe20d605d57
DOI: 10.21203/rs.3.rs-3752711/v1

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