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Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy <sup>1</sup>

2022-07-28

Abstract excerpt

Engineering immune cells with chimeric antigen receptors (CAR) is a promising technology in cancer immunotherapy. Besides classical cytotoxic CD8+ T cells, innate cell types such as NK cells have also been used to generate CAR-T or CAR-NK cells. Here we devised an approach to program a non-classical cytotoxic T cell subset called Mucosal Associated Invariant T (MAIT) cells into effective CAR-T cells against B cell...

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Literature Corpus work
8ebce229-a862-529d-992a-68bb3c1de4d0
DOI
10.1101/2022.07.28.501764
Open publication

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Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy <sup>1</sup>DOI 10.1101/2022.07.28.501764
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