Article

Engineering CAR T Cells for Hepatocellular Carcinoma Recurrence after Liver Transplantation

2026-07-05

Abstract excerpt

<h4>Background & Aims</h4> Liver transplantation improves outcomes in hepatocellular carcinoma (HCC), yet treatment options for patients with tumor recurrence remain limited to tyrosine kinase inhibitors. Glypican-3 (GPC3)-targeted CAR T cells offer a tumor-directed immune-based therapeutic strategy, but their efficacy may be limited by post-transplant immunosuppression. We developed a CAR T cell platform combini...

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Literature Corpus work: 58420a6a-3ff1-5cc8-8806-a461877437e8
DOI: 10.64898/2026.06.30.735569

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