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Trophoblast-Derived Extracellular Vesicles Promote Preeclampsia by Regulating Macrophage Polarization

7 Sept 2022

Abstract excerpt

BACKGROUND: Systemic inflammation caused by dysfunctional macrophages is a crucial pathogenetic event in preeclampsia (PE). Trophoblast-derived extracellular vesicles (T-EVs) are potent immune cell signaling modulators in pregnancy. Herein, we aimed to investigate T-EVs' effect and mechanism on macrophage polarization and its role in PE pathogenesis, which remain unclear. METHODS: Flow cytometry and...

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PMID: 35993233
DOI: 10.1161/hypertensionaha.122.19244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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