Article

ORF3a is a key driver of maternal SARS-CoV-2 infection-associated placental dysfunction

2025-07-03

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 infection during pregnancy is associated with an increased risk of pre-eclampsia (PE), a hypertensive disorder, but the molecular mechanisms remain poorly understood. Here, we identify ORF3a, a SARS-CoV-2 accessory protein, as a key factor in placental dysfunction, driving autophagy dysregulation, trophoblast maturation impairment, protein aggregation and placental barrier di...

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Literature Corpus work: d683bad7-4390-57ff-afc1-eba5d56dd662
DOI: 10.21203/rs.3.rs-6857689/v1

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