Article
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.
RNA (New York, N.Y.) - 1 Mar 2001
Svitkin Y V, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham G J, Sonenberg N
Abstract excerpt
Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome. elF4A possesses ATPase and RNA helicase activities and is the prototype for a large family of putative RNA helicases (the DEAD box family). It is thought that the function of elF4A during translation initiation is to unwind the mRNA secondary structure in the 5'...
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