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Article

JAK inhibitors remove innate immune barriers facilitating viral propagation

2025-02-21

Abstract excerpt

Janus kinase (JAK) inhibitors are small-molecule therapeutics that reduce inflammation in autoimmune and inflammatory diseases by modulating the JAK-STAT pathway. While effective in alleviating immune-mediated conditions, JAK inhibitors can impair antiviral defences by suppressing interferon (IFN) responses, potentially increasing susceptibility to viral infections. This study investigates the pro-viral mechanism...

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Identifiers and source

Literature Corpus work
3c09ca1c-3423-582a-aff4-96b62041b096
DOI
10.1101/2025.02.17.638720
Open publication

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JAK inhibitors remove innate immune barriers facilitating viral propagationDOI 10.1101/2025.02.17.638720
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