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Article

Viral manipulation of STAT3: Evade, exploit, and injure

15 Mar 2018

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer...

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PMID: 29543893
DOI: 10.1371/journal.ppat.1006839

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