Article

In vivo antiviral efficacy and immune dampening effect of zapnometinib emphasize a dual therapeutic potential against COVID-19

2022-02-28

Abstract excerpt

<title>Abstract</title> <p>Coronaviruses, in particular the current pandemic strains of SARS-CoV-2, represent an ever-evolving threat to human life. Currently available antiviral drugs are not suitable for severely infected patients in later hyperinflammatory stages of the disease. New therapeutics that inhibit virus propagation and target inflammation would be ideal. We demonstrate that the host targeted MEK inh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7501fb9e-9894-53ec-8ac2-03bef6799f9c
DOI: 10.21203/rs.3.rs-1381607/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In vivo antiviral efficacy and immune dampening effect of zapnometinib emphasize a dual therapeutic potential against COVID-19DOI 10.21203/rs.3.rs-1381607/v1Read

Molecular Perspectives of SARS-CoV-2: Pathology, Immune Evasion, and Therapeutic InterventionsSemantic proximity Read

Tissue protective role of Ganetespib in SARS-CoV-2-infected Syrian golden hamstersSemantic proximity Read

Therapeutic Approaches for COVID-19 Based on the Dynamics of Interferon-mediated Immune ResponsesSemantic proximity Read

SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virusSemantic proximity Read

JAK inhibitors remove innate immune barriers facilitating viral propagationSemantic proximity Read

Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry PerspectiveSemantic proximity Read

Targeting PI3K Signaling for Broad Inhibition of β-Coronavirus InfectionSemantic proximity Read

Targeting conserved regions of the SARS-CoV-2 polymerase (RdRp) with kinase inhibitors as an effective new tactic for discovering dual-action "antiviral–antiinflammatory" drugs against COVID-19Semantic proximity Read

Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in severe COVID-19Semantic proximity Read

SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replicationSemantic proximity Read

New Insights into SARS-CoV-2 and Cancer Cross-Talk: Does a Novel Oncogenesis Driver Emerge?Semantic proximity Read

Differences in innate Intracellular viral suppression competencies may explain variations in morbidity and mortality from SARS-CoV-2 infectionSemantic proximity Read