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Article

Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.

Development (Cambridge, England) - 31 Jul 2020

Drake Keri A, Chaney Christopher P, Das Amrita, Roy Priti, Kwartler Callie S, Rakheja Dinesh, Carroll Thomas J

Abstract excerpt

Wilms' tumor (WT) morphologically resembles the embryonic kidney, consisting of blastema, epithelial and stromal components, suggesting tumors arise from the dysregulation of normal development. β-Catenin activation is observed in a significant proportion of WTs; however, much remains to be understood about how it contributes to tumorigenesis. Although activating β-catenin mutations are observed in both blastema...

Topics

Animals
Base Sequence
Body Patterning
Cell Differentiation
Cell Lineage
Epithelium
Forkhead Transcription Factors
Gene Expression Regulation, Neoplastic
Humans
Integrases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesoderm

Mice

Mutation

Nephrons

Organogenesis

Osteogenesis

Stem Cells

Stromal Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 32541007
DOI: 10.1242/dev.189597
PMCID: PMC7406317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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